For the Induction of Arthritis in the Collagen Antibody Induced Arthritis Model:

  1. Administer antibody cocktail (IV) on day 0 with 2 mg*
  2. Boost with LPS on day 3 (IP)
  3. Dosing with test material following regime beginning on day 0 or day 3.
  4. Body weights, clinical signs & scoring, rear paw thickness daily (or every other day)
  5. Terminate on day 12
  6. Histopathology

*Needs to be optimized for each laboratory. C57 strains should use optimized ArthritoMab;#0153; Antibody Cocktail (CIA-MAB-2C). Our scientists can assist in setting up the model in each lab, walking through optimizations not only based on your individual vivarium conditions, but also based on your compound requirements. We use a variety of administration routes and compound classes and can assist in recommending the best approach for your situation.

Don't have internal capabilities to run in vivo studies?

MD Biosciences contract research serviceruns the Collagen Antibody Induced Arthritis model using the ArthritoMab™ cocktail on a monthly basis.
Contact a scientist to outsource a study