An alternative Rheumatoid Arthritis Model
The Collagen Antibody-Induced Arthritis (CAIA) model is an excellent alternative to both the CIA and K/BxN models, which both present researchers with challenges of either length of study or expensive colonies to maintain. In the CIA model, researchers must factor in a six-week study and account for therapeutic regime challenges since animals develop disease at varying rates. In the K/BxN model, induction uses sera that contains an undefined polyclonal mix varying from batch to batch. Researchers also need to be prepared for possible colony sickness and the time required for the animals to develop arthritis spontaneously. The CAIA model induced by the ArthritoMab™ Antibody Cocktail enables researchers the ability to rapidly execute studies in 1/3 of the time it takes to run a CIA model and eliminates the variability that applies to the K/BxN model.
Benefits of the Collagen antibody-induced arthritis model (CAIA):
Arthritis develops in mice typically within 24-48 hr allowing the completion of a study within 2 weeks reducing the number of assessments and scoring periods. Significant changes at the histological level are observed.
Rate of incidence is nearly 100% depending on the strain allowing for smaller group sizes. Onset of disease is synchronized between animals simplifying treatment schedules. Disease progression is controlled and steady elimination severe & rapid disease spikes, enabling drug treatment options.
Arthritis is induced not only in CIA-susceptible DBA/1 and B10.RIII mice, but also in some CIA-resistant mice, such as Balb/c. Transgenic strains such as C57Bl/6 are also susceptible with an optimized cocktail, lifting the challenges of using transgenic strains in RA research.
Models such as the K/BxN serum transfer model require labs to maintain expensive colonies and the sera can vary from batch to batch introducing variability. The ArthritoMab™ Antibody Cocktail is constant supply, contains no batch-batch variability and is based on relevant anti-CII Abs
