Using the CAIA model as an alternative to the K/BxN model
K/BxN mice spontaneously develop a severe, chronic, progressive inflammatory arthritis at about 27 days of age. They develop auto-antibodies recognizing glucose-6-phosphate isomerase. Serum from these animals when transferred to recipient animals induce arthritis. The mechanism of action involves complement, mast cells, neutrophils and inflammatory mediators. This model is widely used for..
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